Vitamin D Binding Protein and the Biological Activity of Vitamin D
نویسندگان
چکیده
منابع مشابه
Vitamin D Binding Protein and Vitamin D Levels
1 Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China 2 Clinical Research, Diabetes and Endocrinology, Merck Research Laboratories, 126 East Lincoln Avenue, RY34B-148, Rahway, NJ 07065-0900, USA 3Department of Nutritional Science, Rutgers University, New Brunswick, NJ 08901, USA 4Division of Endocrinology, Metabolism an...
متن کاملVitamin D-binding protein prevents vitamin D deficiency and presents vitamin D for its renal activation.
Two mouse models in which the vitamin D-binding protein (DBP) or megalin, a DBP receptor, were knocked out have recently confirmed that DBP is essential for normal vitamin D homeostasis, and have revealed a major pathway for vitamin D activation (1, 2). DBP is also known as the group-specific component of serum (Gc-globulin). It is a highly polymorphic 58 kDa glycoprotein, which has been used a...
متن کاملThe variation in free 25-hydroxy vitamin D and vitamin D-binding protein with season and vitamin D status
PURPOSE Serum 25-hydroxy vitamin D [25(OH)D] varies greatly with season at northern latitudes. The purpose of this study was to determine if the seasonal variations in serum total 25(OH)D are followed by a concomitant variation in free 25(OH)D or if the variation is damped by alterations in the binding capacity of DBP. METHODS Serum was collected from 540 healthy blood donors (60% men; mean a...
متن کاملVitamin D Binding Protein and Bone Health
Vitamin D binding protein (DBP) is the major carrier protein of 25-hydroxyvitamin D (25(OH) D) in the circulation, where it may serve roles in maintaining stable levels during times of decreased 25(OH) availability and in regulating delivery of 25(OH) D to target tissues. Several genetic polymorphisms of DBP have been described that lead to phenotypic changes in the protein that may affect affi...
متن کاملImmunonephelometric assay of vitamin D-binding protein.
An automated immunonephelometric assay was developed to measure vitamin D-binding protein (DBP) in serum. The assay is described for the Behring Nephelometer System, which uses rabbit anti-DBP antiserum and purified human DBP. The detection limit is 0.05 g/L (0.86 mumol/L), and the working range is less than or equal to 1.60 g/L (27.59 mumol/L). Intra- and interassay CVs of 2.0% and 2.8-3.8% co...
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ژورنال
عنوان ژورنال: Frontiers in Endocrinology
سال: 2019
ISSN: 1664-2392
DOI: 10.3389/fendo.2019.00718